Centuries: 14th century - 15th century - 16th century
- April 26 - The Pazzi attack Lorenzo de' Medici and kill his brother Giuliano during High Mass in the Florence Cathedral.
- December 28 - Battle of Giornico - Swiss troops defeat the Milanese.
- Lorenzo de' Medici becomes sole ruler of Florence
- Grand Prince Ivan III of Moscow conquers Novgorod
- February 7 - Sir Thomas More, statesman and humanist, author of Utopia (+ 1535)
- Baldassarre Castiglione, italian writer and diplomat (the author of The Book of the Courtier - d. 1529).