Centuries: 14th century - 15th century - 16th century
- Ivan III becomes Tsar of the Russians
- Moscow becomes independent from the Empire of the Golden Horde of the Mongols.
- Ludovico Sforza becomes Regent of Milan (reigns until 1499)
- Concorts and co-rulers Ferdinand II of Aragon and Isabella of Castileinitiate the Spanish Inquisition (looking for heretics in converted Jews)
- Leonardo da Vinci invents the parachute
- Mohamed II fails in his attempt to capture Rhodes from the Knights of Rhodes
- April 14/ April 18 - Lucrezia Borgia, illegitimate daughter of Rodrigo Borgia, the later Pope Alexander VI (d. 1519).
- Ferdinand Magellan, Portuguese navigator (d. 1521)
- Georg Faust, originator of Faust legend
- Palma Vecchio, Italian painter (d. 1528)