Alexander Fleming House was a multi-storey office building designed by Hungarian-born architect Erno Goldfinger and constructed in the early 1960s to be the headquarters of the Department for Health and Social Security.

It is located on Newington Causeway on the east side of the busy Elephant and Castle junction in the London Borough of Southwark in south-east London.

The building, some 55m tall at its highest point, became notorious for sick building syndrome and the DHSS civil servants were eventually moved out. After sitting empty for some years, the building was eventually converted to residential use in 1998, and renamed "Central Heights".