Alfonso de Albuquerque (1453-1515) was a Portuguese commander.

He sailed around the Cape of Good Hope to India in 1503 and made the first Portuguese settlement there. Three years after he went again and attacked the island of Ormuz in the Persian Gulf, but he was driven off.

Having been made governor and commander-in-chief, he captured Goa in 1510 and Malacca in 1511.

In 1513 he entered the Red Sea with the first European fleet ever seen in its waters, and two years after took Ormuz.