The Antiochian Orthodox Church is one of the five churches that comprised the One Holy Catholic and Apostolic Church before the Great Schism, and today is one of the autocephalous Eastern Orthodox Churches. Its North American branch is autonomous, i.e., although the Patriarch of Antioch appoints its head bishop, he exercises no further authority over it.

The seat of the patriarchate was formerly Antioch, in what is now Turkey, but is now Damascus, Syria.