Auítzotl (sometimes rendered as Ahuitzotl) was the Aztec ruler of the city of Tenochtitlan. Perhaps the greatest known military leader of Pre-Columbian MesoAmerica, he began his reign by surpressing a Huastec rebellion, and then swiftly more than doubled the size of lands under Aztec dominance. He conquered the Mixtec, Zapotec, and other peoples from Mexico's Pacific coast down to the western part of Guatemala. Auitzotl also supervised a major rebuilding of Tenochtitlan on a grander scale.

Auitzotl took power in 1486; his reign was preceded by Tízoc and followed by Moctezuma II.