There several communities in the United States with the name Big Run
- Big Run in Athens County, Ohio
- Big Run in Franklin County, Ohio
- Big Run in Pike County, Ohio
- Big Run in Centre County, Pennsylvania
- Big Run in Clearfield County, Pennsylvania
- Big Run in Dauphin County, Pennsylvania
- Big Run in Jefferson County, Pennsylvania
- Big Run in Marion County, West Virginia
- Big Run in Marshall County, West Virginia
- Big Run in Pocahontas County, West Virginia
- Big Run in Webster County, West Virginia
- Big Run in Wetzel County, West Virginia
Big Run is also the name of a computer game, see Big Run (game)
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