Botolph Claydon is a hamlet in the parish of East Claydon, in Buckinghamshire, England. It is situated about 9 miles east of Bicester in Oxfordshire, and 7 miles north west of Aylesbury.

Anciently the hamlet was called Bottle Claydon. The prefix comes from the Anglo Saxon word botl meaning 'house'. The word Claydon is also Anglo Saxon, and means 'clay hill'.