Boutros Ghali (1846 - February 20, 1910) was the only Coptic Prime Minister of Egypt.

On February 20, 1910, Ghali was assassinated by Ibrahim Nassif al-Wardani, a young pharmacology graduate who had just returned from the United Kingdom.

His grandson Boutros Boutros-Ghali, who was named after him, would go on to become the Deputy Prime Minister of Egypt and a Secretary-General of the United Nations.