Central Luzon region contains the largest plain of the Philippines and produces most of the country's rice supply. Its provinces are: Aurora, Bataan, Bulacan, Nueva Ecija, Pampanga, Tarlac, and Zambales.

There are twelve cities which include: Balanga from Bataan; Cabanatuan, Gapan, Muñoz, Palayan and San Jose from Nueva Ecija; Olongapo from Zambales; Angeles and San Fernando from Pampanga; San Jose del Monte and Malolos from Bulacan; and Tarlac from Tarlac.

San Fernando City, in Pampanga, is the regional capital. Aurora was transferred from Region IV by Executive Order No. 103.