The Clinton Doctrine is not a clear statement in the way that many other doctrines were. However, in a February 26 1999 speech, President Bill Clinton said the following, which was considered the Clinton Doctrine:

It's easy...to say that we really have no interests in who lives in this or that valley in Bosnia, or who owns a strip of brushland in the Horn of Africa, or some piece of parched earth by the Jordan River. But the true measure of our interests lies not in how small or distant these places are, or in whether we have trouble pronouncing their names. The question we must ask is, what are the consequences to our security of letting conflicts fester and spread. We cannot, indeed, we should not, do everything or be everywhere. But where our values and our interests are at stake, and where we can make a difference, we must be prepared to do so .

Later statements "genocide is in and of itself a national interest where we should act" and "we can say to the people of the world, whether you live in Africa, or Central Europe, or any other place, if somebody comes after innocent civilians and tries to kill them en masse because of their race, their ethnic background or their religion, and it's within our power to stop it, we will stop it" augmented the doctrine of interventionism.

The Clinton Doctrine was used to justify the American involvement in the War in Yugoslavia.