Colossus refers to something which is very large or powerful.
- the Colossus of Rhodes, one of the Seven Wonders of the World
- the Colossus computer, the world's first digital programmable electronic computer
- the novel and movie, Colossus: The Forbin Project
- Colossus, a fictional computer featured in the above novel and movie, Colossus: The Forbin Project
- Colossus, one of the X-Men