City in the province of Verbano-Cusio-Ossola, in the region ofPiedmont, Italy, earlier known as Oscela, Oscella, Oscella dei Leponzi, Ossolo, Ossola Lepontiorum, and Domo d'Ossolo.

Domodossola was the chief town of the Lepontii when the Roman Empire conquered the region in 12 B.C.

Domodossola is situated at the junction of the Bogna and Toce Rivers, and is home to 18,500 people, mostly Italian speaking and Roman Catholic in religion.