ER is a popular NBC drama primarily set in a teaching hospital's emergency room, the fictional County General (based loosely off Cook County General, a real hospital) in Chicago, Illinois. The first episode, known as "24 Hours" or simply "Pilot", aired in the United States on September 19, 1994.

Current stars of the series include:

  • Noah Wyle (Series 1 to present), as Dr. John Carter
  • Laura Innes (Series 2 to present), as Dr. Kerry Weaver
  • Alex Kingston (Series 4 to present), as Dr. Elizabeth Corday
  • Ming-Na (Series 1, 6 to present), as Dr. Jing-mei (Deb) Chen
  • Goran Visnjic (Series 6 to present), as Dr. Luka Kovac
  • Maura Tierney (Series 6 to present), as Nurse Abby Lockhart
  • Sherry Stringfield (Series 1-3, 8 to present), as Dr. Susan Lewis
  • Sharif Atkins (Series 7 to present), as Dr. Michael Gallant
  • Mekhi Phifer, (Series 9 to present), as Dr. Greg Pratt
  • Parminder Nagra (Series 10 to present), as Neela Rasgotra
  • Linda Cardellini (Series 10 to present), as Nurse Samantha Taggart

Former cast members include:
  • Anthony Edwards (Series 1-8), as Dr. Mark Greene
  • Eriq La Salle (Series 1-8), as Dr. Peter Benton
  • Julianna Margulies (Series 1-6), as Nurse Carol Hathaway
  • George Clooney (Series 1-5), as Dr. Doug Ross
  • Paul McCrane (Series 4-10), as Dr. Robert 'Rocket' Romano
  • William H. Macy (Series 1-4), as Dr. David Morgenstern
  • Kellie Martin (Series 4-6), as Lucy Knight
  • Gloria Reuben (Series 1-5), as Jeanie Boulet

It has won at least one Emmy every year of its production up to and including the 2002 awards and has won the People's Choice Award for Favorite Television Dramatic Series every year from 1997 to 2002. Over the years, it has been nominated for and/or won numerous other awards including BAFTAs, Screen Actors Guild awards, TV Guide awards, Image awards, GLAAD awards and Golden Globes.

The complete first season of ER was released on DVD on August 26, 2003.

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