The International Space Hall of Fame sits on the western face of the Sacramento Mountain range of New Mexico. The building overlooks Alamogordo, New Mexico, the White Sands, Holloman Air Force Base, the White Sands Missile Range, and the Jornada del Muerto, to the west. Framing this scene to the west lie the Organ mountains, behind which lies Las Cruces, New Mexico. Behind the building, to the east, lies the pine forested mountains leading upward to Cloudcroft and Ruidoso, the home of the Mescalero Apache.

The museum contains samples of booster rockets, nose cones, and an exhibit on the planets of the solar system, space flight, and a small display on the primates who were used in the early space flight experiments in the U.S.