Interstate 81 is an interstate highway in the eastern part of the United States. Its southern terminus is at Interstate 40 near Dandridge, Tennessee; its northern terminus is at Fishers Landing, New York at the Canadian border.

Table of contents
1 Distances by state
2 Major cities along the route
3 Intersections with other Interstates
4 Spur routes
5 Notes

Distances by state

Total - 824 miles (1326km)

Major cities along the route

Intersections with other Interstates

Spur routes

Notes

This road is a "line on a map" Interstate. Mainly it exists so more people can have a path through the
Appalachians than to relieve congestion on that busy Roanoke-Harrisburg route.

I-81 runs together with Interstate 77 in Wytheville, Virginia for about 10 miles (16km), but the two go in opposite directions. Motorists traveling northbound on I-81 are also traveling southbound on I-77, though they are actually going east. Likewise, motorists traveling southbound on I-81 are also traveling northbound on I-77, though they are actually going west.