Jacquetta de Luxembourg (1415/1416 - May 30, 1472) was daughter of Pierre de Luxembourg, Comte de Saint Pol, Conversano et Brienne and his wife Margaret de Baux (Margherita del Balzo of Andria).

On April 22, 1433 she married John, Duke of Bedford (son of King Henry IV of England) at Therouenne. This marriage was childless. He died in the night of September 14/15, 1435.

Before March 23, 1436/1437, she married Sir Richard Woodville, who was the son of her dead husband's chamberlain. He was later created 1st Earl Rivers. They had sixteen children, among them Elizabeth Woodville who was to become the wife of King Edward IV of England, and mother of Elizabeth of York (in her turn mother of King Henry VIII) and of King Edward V.