The Jefferson Highway was an automobile highway stretching through the central United States from New Orleans, Louisiana to Winnipeg, Manitoba, Canada. It was build in the 1910s.
The Jefferson Highway was inspired by the east-west Lincoln Highway.
It was nicknamed the "Palm to Pine Highway", for the varying types of trees found at either end.
The cities the highway passed on its route included Alexandria, Louisiana, Shreveport, Louisiana, Marshall, Texas, Muskogee, Oklahoma, Baxter Springs, Kansas, Kansas City, Missouri, St. Joseph, Missouri, Des Moines, Iowa, Minneapolis, Minnesota, and Bemidji, Minnesota.