Margaret de Clare (1293-1342) was one of the three daughters of Gilbert de Clare, 3rd Earl of Gloucester and his wife, Joan of Acre. and thus a granddaughter of King Edward I of England.

Following the death of their brother, Gilbert de Clare, 4th Earl of Gloucester, at the Battle of Bannockburn in 1314, Margaret and her sisters each received a share of the inheritance. Margaret's first husband was Piers Gaveston, favourite of King Edward II. Following Gaveston's execution in 1312, she married Hugh de Audley. There were children from both marriages.