The Central African Republic includes many different cultures and musical forms. Western rock and pop music, as well as Afrobeat, soukous and other genres have become popular nation-wide. The sanza is a popular instrument.

The Pygmies have an incredibly complex folk music tradition. Polyphony and counterpoint are common components, as is an incredibly varied rhythmic structure. The trumpet-based music of the Bandas has also gained some popularity outside of the area due to its jazzy structure. The Ngbaka use an unusual instrument called a mbela, which is made with an arched branch and a string strung between the two ends and held in front of the musician's mouth. When the string is struck, the mouth is used to amplify and modulate the tone. Instruments similar to the mbela are sometimes considered the oldest ancestors of all string instruments.