In Star Trek: The Next Generation, Dr. Noonien Soong, (played by Brent Spiner) is a cyberneticist who lived on the colony Omicron Theta for several years, where he created six androids with positronic brains, the last two being Lore and Data.

In 2328, Dr. Soong married Dr. Juliana O'Donnell, also a cyberneticist, who died shortly after the Crystalline Entity attack on the colony, but most of her memories remain inside an android created by Dr. Soong. He was presumed dead himself, but was discovered to be alive in 2367. He died soon on stardate 44085.7 on Terlina III, where he built his last laboratory.

Although Dr. Noonien Soong's ancestry is not explicitly stated in the canon, his name is East Asian, either Chinese or Korean. Soong is a popular Chinese surname (宋) and Korean surname (송).

Some of the O'Donnell android's memories were fragmentary, such as the death of Dr. Soong and her creation as an android. Dr. O'Donnell later remarried to Dr. Pran Tainer of Atrea IV, where Data discovered that O'Donnell is his creation mother (since Data's memories were erased during the Crystalline Entity attack).

Not to be confused with Khan Noonien Singh, the infamous selectively bred human of the late 1990s, which most likely is not connected, at least not in the canonic texts and information.