Pike can mean:
- A pole weapon, see pike (weapon)
- A carnivorous fish, see pike (fish)
- A programming language, see pike programming language
- The fraternity Pi Kappa Alpha
- Stream cipher Pike (cryptography)
- A male elf character (skilled with his namesake weapon) in the comic book Elfquest
- Albert Pike (military officer)
- Frank Pike, fictional Home Guard member in Dad's Army and It Sticks Out Half a Mile
- Kenneth L. Pike (linguist and anthropologist)
- Rosamund Pike (actress)
- Zebulon Pike (military officer and explorer)