The Pond Creek National Wildlife Refuge is a 27,300 acre wildlife refuge located in Sevier County, Arkansas managed by the United States Fish and Wildlife Service.

The Pond Creek National Wildlife Refuge was created in 1994 and is located approximately 30 miles north of Texarkana, Arkansas and 10 miles southeast of De Queen, Arkansas. The western boundary of the refuge is 10 miles from the Arkansas-Oklahoma border.

Pond Creek is made up of various rivers, oxbow lakes, sloughss, and bottomlands hardwood areas.

Pond Creek was created in order to protect the wetland and bottomland hardwood habitat and to serve as a habitat for neo-tropical migratory birds. It also serves as an important nesting habitat for wood ducks and wintering habitat for other migratory waterfowl. It is located where the Mississippi and Central Flyways intersect.