Preparation H is a popular medication used in the treatment of hemorrhoids. It was originally packaged in a tube like toothpaste, with a similar consistency. Wyeth Consumer Healthcare, the makers of Preparation H, have also released the product in a medicated pad form. The tubular packaging is by far the most purchased of the two. Preparation H is also available in a suppository form.

The Canadian formulation of Preparation H includes a yeast extract which has been removed from the formulation sold in the United States. This yeast extract is believed by many to remove wrinkles from skin, and the Canadian formulation has acquired a market in the United States as a skin cream.

In the 1960s Preparation H used the slogan "Effective even in cases of long standing".

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