For Isaac Newton's 1687 book containing basic laws of physics, see Philosophiae Naturalis Principia Mathematica.
The Principia Mathematica is a three-volume work on the foundations of mathematics, written by Bertrand Russell and Alfred North Whitehead and published in 1910-1913. It is an attempt to derive all mathematical truths from a well-defined set of axioms and inference rules in symbolic logic. The main inspiration and motivation for the Principia was Frege's earlier work on logic, which had led to some contradictions discovered by Russell. These were avoided in the Principia by building an elaborate system of types: a set has a higher type than its elements and one can not speak of the "set of all sets" and similar constructs which lead to paradoxes (see Russell's paradox).
The Principia only covered set theory, cardinal numbers, ordinal numbers and real numbers; deeper theorems from real analysis were not included, but by the end of the third volume it was clear that all known mathematics could in principle be developed in the adopted formalism.
The questions remained whether a contradiction could be derived from the Principia's axioms, and whether there exists a mathematical statement which could neither be proven nor disproven in the system. These questions were settled, in a rather disappointing way, by Gödel's incompleteness theorem in 1931.