Santo Trafficante, Jr. (November 15, 1914 - March 17, 1987) was one of the last of the old-time Mafia bosses in the United States. He controlled organized criminal operations in Florida, which had previously been consolidated from several rival gangs by his father, Santo Trafficante, Sr He was also reputedly the most powerful mafioso in Batista-era Cuba.

Trafficante was born in Tampa, Florida to Sicilian parents Santo Trafficante, Sr. and his wife Maria Giuseppa Cacciatore in 1914. He maintained several houses in Tampa and Miami, and also frequented Havana, Cuba (while Batista was in power), and New York City.

Treasury Department documents indicate that law enforcement believed Trafficante's legitimate business interests to include several legal casinos in Cuba; a Havana drive-in movie theatre; and shares in the Columbia Restaurant and several other restaurants and bars in Tampa. He was rumoured to be part of a Mafia syndicate which owned many other Cuban hotels and casinos.

Trafficante was arrested frequently throughout the 1950s on various charges of bribery and of running illegal bolita lotteries in Tampa's Ybor City district. He escaped conviction all but once, receiving a five year sentence in 1954 for bribery, but his conviction was overturned by the Florida State Supreme Court before he entered prison.

Trafficante was arrested in 1957 along with 56 other mobsters at an apparent underworld convention in Apalachin, New York. Charges were later dropped, though authorities believe the meeting was set up, among other things, to authorize the assassination of Murder, Inc head Albert Anastasia. Trafficante later denied knowledge of the circumstances of Anastasia's death.

After Fidel Castro's revolutionary government seized the assets of his Cuban businesses and expelled him from the country as an "undesirable alien", Trafficante reportedly came into contact with various CIA operatives, and was reportedly involved in several unsuccessful plans to assassinate Castro.

He is rumoured to have had interests in narcotics trafficking, and is believed to have set up several drug smuggling routes from South America and Southeast Asia to the United States.

Trafficante was summoned to court in 1986 and questioned about his involvement with the King's Court nightclub operated by members of the Bonanno family from New York, including undercover FBI agent Joe Pistone, alias Donnie Brasco. Trafficante again escaped conviction.

Trafficante's health had declined in his older years, and he died in Houston, Texas, where he had gone for heart surgery, in 1987.

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