Semele is a secular secular oratorio by George Frideric Handel. The libretto was based on a work of William Congreve with additions by Alexander Pope, which drew on the Greek myth of Semele.

It was first performed in London in 1744.

Semele is performed regularly in concert halls and ocassionally staged as an opera, but is not part of the standard operatic repertoire. There are a several recordings of it.

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