Skywest acts as a subsidiary for United Airlines as United Express, Delta Air Lines as Delta Connection, and Continental Airlines as Continental Connection. Skywest flies United Express flights out of Los Angeles, California's Los Angeles International Airport, San Francisco, California's San Francisco International Airport, and Denver, Colorado's Denver International Airport. They fly Delta Connection operations from Salt Lake City International Airport in Salt Lake City, Utah, and Dallas/Fort Worth International Airport in a location between Dallas, Texas and Fort Worth, Texas.

They fly Continental Connection operations from George Bush Intercontinental Airport in Houston, Texas. They have a fleet consiting of the Canadair Regional Jet 100, and the Embraer EMB-120. The former is used on United Express and Delta Connection operations only, and the latter is used on all three (Delta Connection, Continental Connection, United Express) operations. They operate to destinations in the United States and Canada.

Skywest's IATA call code is 00.