Spirit may refer to:
- A spiritual being
- alcohol or a distilled alcoholic beverage, (not wine or beer)
- The B-2 Spirit (official name of the United States Air Force's stealth bomber)
- Spirit Airlines, a Florida-based airline company using McDonnell Douglas DC-9 jets to fly around Florida cities, to the Northeast and Luis Munoz Marin International Airport in Puerto Rico
- The Holy Spirit
- A 1970s psychedelic band: see Spirit (band)
- A Flemish social-democratic political party, forming a cartel with the socialist party SP.a: see Spirit (political party)
- The soul of a person
- NASA's Mars Exploration Rover Mission rover MER-A, named "Spirit"