De Soto is the name of several places in the United States of America presumably all named for the explorer Hernando de Soto:
- De Soto, Georgia
- De Soto, Illinois
- De Soto, Iowa
- De Soto, Kansas
- De Soto, Mississippi
- De Soto, Missouri
- De Soto, Nebraska
- De Soto, Texas
- De Soto, Wisconsin
- De Soto Parish, Louisiana
De Soto was also the name of an automobile manufactured by Chrysler Corporation.
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