Denham is a village in Buckinghamshire, England. It is located just north west of Uxbridge, at junction 1 of the M40.

The village name is Anglo Saxon in origin, and means 'homestead in a valley'. It was listed in the Domesday Book of 1086 as Deneham. The parish church is dedicated to St Mary.

Modern day Denham is a haven for the rich, and is one of the most expensive places in the United Kingdom in which to purchase a house. One of its more famous residents is Cilla Black.