The Dominican Republic has a close relationship with the United States and with the other states of the Inter-American system. It has accredited diplomatic missions in most Western Hemisphere countries and in principal European capitals. The Dominican Republic maintains official relations with the Republic of China (commonly known as "Taiwan") instead of the People's Republic of China. The Dominican Republic and Cuba recently established consular relations, and there is contact in fields such as commerce, culture, and sports. Although Dominican relations with its closest neighbor, the Republic of Haiti, have never been extensive, there are signs this will change with the new government of President Mejia. Growing immigration from and political instability in Haiti have forced the Dominican Republic to take a closer look at relations with its neighbor both country-to-country and in international fora. There is a sizeable Haitian migrant community in the Dominican Republic.

The Dominican Republic belongs to the United Nations and many of its specialized and related agencies, including the World Bank, International Labor Organization, International Atomic Energy Agency, and International Civil Aviation Organization. It also is a member of the OAS, the Inter-American Development Bank, and INTELSAT.

Illicit drugs: transshipment point for South American drugs destined for the US and Europe