In 2003, a group of American and Canadian researchers published a paper that used gene linkage techniques to identify a mutation in the GRK3 gene as a possible cause of up to 10% of cases of bipolar disorder. This gene is associated with a kinase enzyme called G protein receptor kinase 3, which appears to be involved in dopamine metabolism, and may provide a possible target for new drugs for bipolar disorder.
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References:
- T B Barrett, R L Hauger, J L Kennedy, A D Sadovnick, R A Remick, P E Keck, S L McElroy, M Alexander, S H Shaw, and J R Kelsoe, "Evidence that a single nucleotide polymorphism in the promoter of the G protein receptor kinase 3 gene is associated with bipolar disorder", in Molecular Psychiatry, 2003, Volume 8, Number 5, Pages 546-557.
