Hemolysis (alternative spelling Haemolysis) is the excessive breakdown of red blood cells. When this happens in an animal, it causes a form of anemia.

Hemolysis is also an important factor in medical tests, as a blood sample may become hemolysed with prolonged storage, or during venipuncture. This may cause interference with the test results for a patient.

Table of contents
1 Hemolytic anaemia
2 Detection of hemolysis
3 Causes of hemolysis

Hemolytic anaemia

Normally, a red blood cell survives 90 to 120 days in circulation: about 1% of human red blood cells break down each day, which matches the production rate.

When the rate of breakdown increases, the body compensates by producing more red blood cells. If compensation is adequate there are few clinical problems.

If breakdown occurs at such a rate that it exceeds the body's ability to keep up, and then anemia develops.

Detection of hemolysis

Hemolysis can be distinguished from other forms of anemia in several ways:

Causes of hemolysis

  • Autoimmune disease (antibodies)
  • Abnormal red cells, e.g., hereditary spherocytosis
  • Drug + antibody (i.e., some drugs lead to haemolysis mediated by an antibody)
  • G6PD deficiency and other enzyme deficiencies
  • Mechanical (heart valves, microvascular disease)
  • Toxins (e.g., snake venom)

Ineffective hematopoiesis is sometimes misdiagnosed as hemolysis.
  • Clinically these conditions may share may features of hemolysis
  • Red cell breakdown occurs before a fully developed red cell is released into the circulation.
  • Examples: thalassemia, myelodysplastic syndrome