The Long Island Expressway (Interstate 495, one of several roads sharing that designation) extends the length of Long Island. It begins in New York City, at the eastern end of the Queens-Midtown Tunnel, and runs through Queens and into Nassau and Suffolk counties, ending just before the "fish-tail" (where the island splits into northern and southern forks). Smaller highways continue on from the end of the LIE to Greenport on the North Fork and past the Hamptons to Montauk on the South Fork. Cynics have suggested that the acronym is appropriate, in that the term "expressway" is a lie.

In 1999, an HOV lane was added from Deer Park to (near) Hicksville.

A movie called "L.I.E." was also made.