Ma Su was a general for Liu Biao of the Han dynasty in China until the death of Liu Biao in 199 AD. Zhuge Liang saw his skills as a sorcerer, archer and general and invited him to join Liu Bei's army of Shu. He accepted.

He was very useful against the forces of the south like Nanman and Wu. But he made a mistake in the north against Cao Cao and Wei, so Zhuge Liang executed him in 219 AD.