Proton pump inhibitors is a group of drugs whose main action is pronounced and long-lasting reduction of gastric acid production. The group followed another group of pharmaceuticals with similar action called H2 antagonists. Proton pump inhibitors act by blocking the hydrogen-potassium adenosine triphosphatase enzyme system (the so called proton pump ) of the gastric parietal cell. Hence the enzyme inhibited is the terminal stage in gastric acid production. These drugs are utilized in the treatment of many conditions such as:

Clinically used proton pump inhibitors:
  • Omeprazole (brand names: Prilosec, Losec)
  • Lansoprazole (brand names: Prevacid)
  • Esomeprazole (brand names: Nexium)
  • Pantoprazole (brand names: Protonix)
  • Rabeprazole (brand names: Aciphex)