The Roman Inquisition began in 1542 when Pope Paul III established the Holy Office as the final court of appeal in trials of heresy and served as an important part of the Counter-Reformation. In reaction to the excesses of the Spanish Inquisition, it was tightly controlled by strict procedural rules under the administration of Francisco Peņa.

Among the subjects of this Inquisition were Francesco Patrizi, Giordano Bruno, Tommaso Campanella, and Galileo Galilei. Of these, only Bruno was executed; Galileo died under house arrest and Campanella spent many years in prison.

See also the fuller article at Inquisition, and other articles concerning specific institutions at Medieval Inquisition, and Spanish Inquisition.

See also: Congregation for the Doctrine of the Faith