SA or sa may stand for:
- arsine, a toxic gas
- samarium, until the 1920s, when the symbol Sm became universal
- Salvation Army
- San Antonio
- Saudi Arabia (ISO country code)
- seaman apprentice
- selective availability, the mechanism for deliberately degrading the precision of the civilian GPS network
- sine anno, used in bibliographies to indicate that a publication date is unknown
- social anxiety (also known as "social phobia" or "social anxiety disorder")
- Socialist Alliance
- Sociedad Anónima (Spanish), see S.A. (corporation)
- Société Anonyme (French), see S.A. (corporation)
- South Africa
- South America
- South Australia
- structured analysis (software engineering)
- Sturmabteilung (SA, Storm Troopers as in Nazi Germany)
- surface-to-air missile
- system administrator (computer industry)