In the fictional universe of Star Trek, "Species 8472" is the name (designated by the Borg) of an advanced alien life-form that lives in the realm of fluidic space.
They have a dense genetic structure with triple-helix DNA and a powerful immune system. Their anatomy is unique in that they possess three legs and communicate exclusively through telepathy. Their technology, including starships and weapons, is mainly biological.
Species 8472 were discovered by the Borg—who were unable to assimilate them—in the 2370s. This invasion of their realm provoked a war, the first real threat the Borg faced in thousands of years, wiping out trillions of drones.
The 8472s were forced to retreat when the crew of the starship Voyager armed warheads with modified nanoprobess, capable of killing the 8472s.
When they retreated back to fluidic space, one member was left behind, and was relentlessly hunted by a group of Hirogen for several months.
Concerned about the threat posed by Humanity, the 8472s built a space station in normal space and recreated Starfleet Academy within, as a training ground for potential infiltration. The plan was uncovered and disuaded(?) by the crew of Voyager.Anatomy
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