The first USS Columbus of the US Navy was a 24-gun armed ship built at Philadelphia in 1774 as Sally, displacing 200 tons. She was purchased for the Continental Navy in November 1775, Captain A. Whipple in command, armed with 18 9-pounder guns, 10 6-pounder guns, and a crew of 220 to work them.

Between 17 February and 8 April 1776, in company with the other ships of Commodore E. Hopkins' squadron, Columbus took part in the expedition to New Providence, Bahamas, where the first Navy-Marine amphibious operation seized essential military supplies. On the return passage, the squadron captured the British schooner, Hawk, on 4 April, and brig Bolton on the 5th. On 6 April the squadron engaged HMS Glasgow (20). After 3 hours the action was broken off and Glasgow escaped, leaving her tender to be captured. Later in 1776 Columbus cruised off the New England coast taking five prizes. Chased ashore on Point Judith, Rhode Island, 27 March 1778 by a British squadron, Columbus was stripped of her sails, most of her rigging, and other usable material by her crew before being abandoned. She was burned by the enemy.