Waddesdon is a village in the Vale of Aylesbury in Buckinghamshire, England, 6 miles from Aylesbury, on the A41. The centre of a parish including the hamletss of Eythrope, Westcott, Wormstone and Woodham, Waddesdon was an agricultural settlement with milling, silk weaving and lace making enterprises. The parish church of St Michael and All Angels dates from 1190 with medieval and Victorian additions.

Between 1897 and 1936 Waddesdon had train services on the Aylesbury and Buckingham Railway at Waddesdon Manor Station, two miles from the village.

In 1874 Baron Ferdinand de Rothschild bought a large estate in the area and built the mansion of Waddesdon Manor on a hill-top above the village. He transformed Waddesdon into an estate village, with new houses for employees and tenants, a school, a public house, cricket pavilion and village hall.

Waddesdon Manor and grounds are now the property of the National Trust, and Jacob, 4th Lord Rothschild retains the estate and a house at nearby Eythrope.